Measles causes amnesia of the immune system
Reporter and Curator: Dr. Sudipta Saha, Ph.D. One of the most contagious diseases known to humankind, measles killed an average of 2.6 million people each year before a vaccine was developed,...
View ArticleImpaired antibody development is promoted by chronic viral infection
Reporter and Curator: Dr. Sudipta Saha, Ph.D. Effective humoral immune responses to infection and immunization are defined by high-affinity antibodies generated as a result of B cell differentiation...
View ArticlePredicting the Protein Structure of Coronavirus: Inhibition of Nsp15 can slow...
Predicting the Protein Structure of Coronavirus: Inhibition of Nsp15 can slow viral replication and Cryo-EM – Spike protein structure (experimentally verified) vs AI-predicted protein structures (not...
View ArticleStructure-guided Drug Discovery: (1) The Coronavirus 3CL hydrolase (Mpro)...
Structure-guided Drug Discovery: (1) The Coronavirus 3CL hydrolase (Mpro) enzyme (main protease) essential for proteolytic maturation of the virus and (2) viral protease, the RNA polymerase, the viral...
View ArticleActemra, immunosuppressive which was designed to treat rheumatoid arthritis...
Actemra, immunosuppressive which was designed to treat rheumatoid arthritis but also approved in 2017 to treat cytokine storms in cancer patients SAVED the sickest of all COVID-19 patients Reporter:...
View ArticleRNA from the SARS-CoV-2 virus taking over the cells it infects: Virulence –...
RNA from the SARS-CoV-2 virus taking over the cells it infects: Virulence – Pathogen’s ability to infect a Resistant Host: The Imbalance between Controlling Virus Replication versus Activation of the...
View ArticlePharmaceutical Companies Racing Together to Find a Cure for COVID-19
Pharmaceutical Companies Racing Together to Find a Cure for COVID-19 Reporter: Irina Robu, PhD The global outbreak has put pressure on companies and the Food and Drug Administration (FDA) to act...
View ArticleInhibitory CD161 receptor recognized as a potential immunotherapy target in...
Inhibitory CD161 receptor recognized as a potential immunotherapy target in glioma-infiltrating T cells by single-cell analysis Reporter: Dr. Premalata Pati, Ph.D., Postdoc Brain tumors, especially...
View ArticleEight Subcellular Pathologies driving Chronic Metabolic Diseases – Methods...
Eight Subcellular Pathologies driving Chronic Metabolic Diseases – Methods for Mapping Bioelectronic Adjustable Measurements as potential new Therapeutics: Impact on Pharmaceuticals in Use Curators:...
View ArticleRegulatory T cells (Tregs) are important for sperm tolerance and male fertility
Regulatory T cells (Tregs) are important for sperm tolerance and male fertility Reporter and Curator: Dr. Sudipta Saha, Ph.D. Regulatory T cells (Tregs) are specialized immune cells that modulate...
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